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Deborah BOURC’HIS – UMR 3215 – INSERM U934, « Epigenetic Decisions and Reproduction», Institut Curie, Paris, France

DNA methylation is a prevalent epigenetic mark in mammalian genomes, with essential roles for development. Over the past years, our team has made significant contribution towards understanding the role of this mark for spermatogenesis and male fertility. I will present our latest work that demonstrates that sperm production relies on a division of labor between two DNA methylation enzymes, with specialized and non-redundant functions: transposon control or stem cell homeostasis.