Clonal hematopoiesis driven by chromosome 1q/MDM4 trisomy defines a canonical route toward leukemia in Fanconi anemia

Marie Sebert, Stéphanie Gachet, … and Jean Soulier

In the FA background of chromosomal instability & HSC attrition, trisomy 1q/MDM4-driven p53 downregulation yields clonal hematopoiesis, preceding sAML.